Maria Cristina Vigone

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Specialty:

Pediatrics

Profession:

Endocrinologist

Location:

Department of Pediatrics @ Ospedale San Raffaele

Languages:

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Biography

Dr. Maria Cristina Vigone is a pediatrician and Head of the Thyroid Pathology Clinic at the Pediatric and Neonatology Unit of IRCCS San Raffaele, led by Dr. Graziano Barera.

After graduating in Medicine and Surgery in 1994 from the University of Milan, she specialized in Pediatrics in 2000 and in Neonatology and Neonatal Pathology in 2002.

Since 2001, she has been a tutorial lecturer for professional training activities at Vita-Salute San Raffaele University in Milan for the General and Specialized Pediatrics course, and a co-supervisor for degree theses in Medicine and Surgery and specialization theses in Pediatrics. Since 2018, she has been involved in teaching for the Master’s program in Pediatric Endocrinology and Diabetology at Vita-Salute San Raffaele University.

From 2000 to the present, she has worked at the Pediatric and Neonatology Unit of the San Raffaele Scientific Institute in Milan.

Between 2009 and 2011, she served as Coordinator of the Thyroid Disease Study Group of the Italian Society of Pediatric Endocrinology and Diabetology. She held the same position between 2015 and 2017.

From 2015 to 2016, she participated in the Iodine Task Force led by Prof. M. Maghnie.

From September 2017 to November 2021, she was a member of the Executive Board of the Italian Society of Pediatric Endocrinology and Diabetology.

Her clinical-assistance activity at the Pediatric Unit covers:

Pediatrics I and II inpatient wards
Day Hospital
General pediatrics and pediatric endocrinology clinics

Dr. Vigone also manages a multidisciplinary outpatient clinic for follow-up of patients with congenital hypothyroidism and childhood thyroid diseases.

Her scientific research focuses on childhood thyroid pathology, particularly:

Congenital hypothyroidism
Autoimmune thyroid diseases
Polyglandular syndromes
Thyroid nodular pathology.

Education

University of Milan
Degree in Medicine and Surgery - 1994

University of Milan
Specialization Diploma in Pediatrics - 2000

University of Milan
Specialization Diploma in Neonatology and Neonatal Pathology - 2002

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Publications

Latest publications

Treatment of congenital hypothyroidism: comparison between L-thyroxine oral solution and tablet formulations up to 3 years of age

(2021) European journal of endocrinology, 186 (1), pp. 45-52. DOI: 10.1530/EJE-20-1444

Vigone, M.C., Ortolano, R., Vincenzi, G., Pozzi, C., Ratti, M., Assirelli, V., Vissani, S., Cavarzere, P., Mussa, A., Gastaldi, R., Di Mase, R., Salerno, M., Street, M.E., Trombatore, J., Weber, G., Cassio, A.

Thyroid nodular disease and PTEN mutation in a multicentre series of children with PTEN hamartoma tumor syndrome (PHTS)

(2021) Endocrine, 74 (3), pp. 632-637. DOI: 10.1007/s12020-021-02805-y

Tuli, G., Munarin, J., Mussa, A., Carli, D., Gastaldi, R., Borgia, P., Vigone, M.C., Abbate, M., Ferrero, G.B., De Sanctis, L.

Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update - An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology

(2021) Thyroid, 31 (3), pp. 387-419. DOI: 10.1089/thy.2020.0333

Van Trotsenburg, P., Stoupa, A., L√©ger, J., Rohrer, T., Peters, C., Fugazzola, L., Cassio, A., Heinrichs, C., Beauloye, V., Pohlenz, J., Rodien, P., Coutant, R., Szinnai, G., Murray, P., Bart√©s, B., Luton, D., Salerno, M., De Sanctis, L., Vigone, M., Krude, H., Persani, L., Polak, M.

Newborn screening for congenital hypothyroidism: The benefit of using differential TSH cutoffs in a 2-screen program

(2021) Journal of Clinical Endocrinology and Metabolism, 106 (1), pp. E338-E349. DOI: 10.1210/clinem/dgaa789

Caiulo, S., Corbetta, C., Di Frenna, M., Medda, E., De Angelis, S., Rotondi, D., Vincenzi, G., De Filippis, T., Patricelli, M.G., Persani, L., Barera, G., Weber, G., Olivieri, A., Vigone, M.C.

Block-and-replace‚Äù treatment in Graves‚Äô disease: experience in a cohort of pediatric patients

(2020) Journal of Endocrinological Investigation, 43 (5), pp. 595-600. DOI: 10.1007/s40618-019-01144-0

Vigone, M.C., Peroni, E., Di Frenna, M., Mora, S., Barera, G., Weber, G.

Neonatal Screening for Congenital Hypothyroidism: What Can We Learn from Discordant Twins

(2019) Journal of Clinical Endocrinology and Metabolism, 104 (12), pp. 5765-5779. DOI: 10.1210/jc.2019-00900

Medda, E., Vigone, M.C., Cassio, A., Calaciura, F., Costa, P., Weber, G., De Filippis, T., Gelmini, G., Di Frenna, M., Caiulo, S., Ortolano, R., Rotondi, D., Bartolucci, M., Gelsomino, R., De Angelis, S., Gabbianelli, M., Persani, L., Olivieri, A.

Influence of Hashimoto thyroiditis on the development of thyroid nodules and cancer in children and adolescents

(2019) Journal of the Endocrine Society, 3 (3), pp. 607-616. DOI: 10.1210/js.2018-00287

Radetti, G., Loche, S., D'Antonio, V., Salerno, M., Guzzetti, C., Aversa, T., Cassio, A., Cappa, M., Gastaldi, R., Deluca, F., Vigone, M.C., Tronconi, G.M., Corrias, A.

Mild TSH resistance: Clinical and hormonal features in childhood and adulthood

(2017) Clinical Endocrinology, 87 (5), pp. 587-596. DOI: 10.1111/cen.13387

Vigone, M.C., Di Frenna, M., Guizzardi, F., Gelmini, G., de Filippis, T., Mora, S., Caiulo, S., Sonnino, M., Bonomi, M., Persani, L., Weber, G.

Ardissino, D., Weber, G., Gentilini, D., Guizzardi, F., Duga, S., Persani, L. A frequent oligogenic involvement in congenital hypothyroidism

(2017) Human Molecular Genetics, 26 (13), pp. 2507-2514. Cited 78 times. DOI: 10.1093/hmg/ddx145

De Filippis, T., Gelmini, G., Paraboschi, E., Vigone, M.C., Frenna, M.D., Marelli, F., Bonomi, M., Cassio, A., Larizza, D., Moro, M., Radetti, G., Salerno, M.,

Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism

(2014) Journal of Pediatrics, 164 (6), pp. 1296-1302. Cited 63 times. DOI: 10.1016/j.jpeds.2013.12.048

Vigone, M.C., Caiulo, S., Di Frenna, M., Ghirardello, S., Corbetta, C., Mosca, F., Weber, G.

Congenital hypothyroidism treatment in infants: A comparative study between liquid and tablet formulations of levothyroxine

(2014) Hormone Research in Paediatrics, 81 (1), pp. 50-54. Cited 41 times. DOI: 10.1159/000356047

Peroni, E., Vigone, M.C., Mora, S., Bassi, L.A., Pozzi, C., Passoni, A., Weber, G.

The clinical and molecular characterization of patients with dyshormonogenic congenital hypothyroidism reveals specific diagnostic clues for DUOX2 defects

(2014) Journal of Clinical Endocrinology and Metabolism, 99 (3), pp. E544-E553. Cited 57 times. DOI: 10.1210/jc.2013-3618

Muzza, M., Rabbiosi, S., Vigone, M.C., Zamproni, I., Cirello, V., Maffini, M.A., Maruca, K., Schoenmakers, N., Beccaria, L., Gallo, F., Park, S.-M., Beck-Peccoz, P., Persani, L., Weber, G., Fugazzola, L.

Congenital hypothyroidism with eutopic thyroid gland: Analysis of clinical and biochemical features at diagnosis and after re-evaluation

(2013) Journal of Clinical Endocrinology and Metabolism, 98 (4), pp. 1395-1402. DOI: 10.1210/jc.2012-3174

Rabbiosi, S., Vigone, M.C., Cortinovis, F., Zamproni, I., Fugazzola, L., Persani, L., Corbetta, C., Chiumello, G., Weber, G.

Surgical management of pediatric Graves' disease: An effective definitive treatment

(2012) Pediatric Surgery International, 28 (6), pp. 609-614. DOI: 10.1007/s00383-012-3095-5

Peroni, E., Angiolini, M.R., Vigone, M.C., Mari, G., Chiumello, G., Beretta, E., Weber, G.

A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH)

(2009) Clinical Endocrinology, 71 (5), pp. 739-745. DOI: 10.1111/j.1365-2265.2009.03568.x

Corbetta, C., Weber, G., Cortinovis, F., Calebiro, D., Passoni, A., Vigone, M.C., Beck-Peccoz, P., Chiumello, G., Persani, L.

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